Ethylene oxide is generally synthesized by chlorohydrine process and direct oxidation of ethylene with air, catalyzed by silver ag. Ethylene, gaseous c 2h 4 ethylene, liquefied c 2h 4 cryogenic. Ethylene oxide is also used as a sterilizing agent for medical equipment and a fumigating agent for spices. Ethylene oxide 1614 centers for disease control and. The basis for oshas ethylene oxide standard, 29 cfr 1910. Because it is a strained ring, ethylene oxide easily participates in a number of addition. The acute shortterm effects of ethylene oxide in humans consist mainly of central nervous. Ethylene glycol eg is a major industrial chemical used in the production of polyester fibers and films, antifreeze and vitrification formulations, and numerous other applications. Methyloxirane, 12 epoxypropane, methyl ethylene oxide, propylene epoxide.
The method is applicable to shortterm 10min samples. Reactivity of ethylene oxide in contact with contaminants. Stice, in reproductive and developmental toxicology second edition, 2017. The intent is not to provide an exhaustive list of analytical methods that could be used to detect and quantify ethylene oxide. The epoxy cycle of ethylene oxide is an almost regular triangle with bond angles of about 60 and a significant angular strain corresponding to the energy of 105 kjmol. Workers may be harmed from exposure to ethylene oxide. Osha chemical sampling information, accessed 22007. This product may be used only in facilities that meet the requirements of the ethylene oxide standard 29 cfr 1910. Although not every sample will be exactly 8 hours, the osha action level and 8hour permissible exposure limit must only be compared to an 8hour sample result. It is produced by direct oxidation of ethylene with air or oxygen. Us epa, pesticide product label, ethylene oxide, 052020. Ambient ethylene concentrations can vary, but are typically less than 0. Ethylene oxide by portable gc 3702 wikisource, the.
Reason for citation ethylene is on the hazardous substance list because it is cited by acgih, dot, dep, nfpa and epa. Ethylene oxide vapor may be initiated into explosive decomposition in absence of air hess, l. The principal application of ethylene oxide is the manufacture of ethene glycol or ethylene glycol and higher alcohols used in automotive antifreeze, explosives, cellophane, synthetic rubbers and lubricants as well as solvents and hydraulic fluids. Claesson, and martin malmsten laboratory for chemical surface science, department of chemistry, physical chemistry, royal institute of technology, s100 44 stockholm, sweden, and. Osha, cma, ansi and canadian whmis standards part i what is the material and what do i need to know in an emergency. The process involves exposing products to ethylene oxide gas under vacuum in a sealed chamber. High purity ethylene oxide hpeo is a colourless, highly reactive and flammable gas at room temperature. P4798 410 this document is only controlled while on the praxair, inc. Corneal injury, liver, and neurological effects have been reported in acutely exposed animals. Health science park 3154 caroline drive haw river, nc 27258 usa information telephone number. It is very water soluble and solutions of as little as 4% in water are flammable. Ethylene oxide eto cas 75218 physical hazards ethylene oxide eto is an extremely flammable and reactive material which is a gas at room temperature. Many samples, including most ethylene oxide samples, can be placed in a plastic zip bag, wrapped in padding, and shipped to the laboratory in a rigid crushproof box.
A small amount less than 1% is used to control insects in some stored agricultural products and a very small amount is used in. Analytical reference materials ethylene oxide standard. Ethylene oxide is a flammable gas with a somewhat sweet odor. Ethylene oxide is a colorless and flammable gas with a faintly sweet odor. Some types of samples, however, require refrigeration or require you to avoid some packaging materials that might contaminate the sample. Safety data sheet creation date 02feb2010 revision date 17jan2018 revision number 4 1. Ethylene oxide, called oxirane by iupac, is an organic compound with the formula c 2 h 4 o. It is not intended to serve as a substitute for indepth training or. This product may be used only in nonportable commercial vacuum or gastight chambers designed for use with 20% ethylene oxide, 80% carbon dioxide. July 1, 2014 the dow chemical company page 4 of 7 ethylene. Styrene oxide is used as a reactive plasticizer or diluent for epoxy resins and in the production of phenethyl alcohol and styrene glycol and its derivatives. Dow ethylene oxide eo is a colorless, flammable, reactive material with a somewhat sweet, etherlike odor. Identification of the substancemixture and of the companyundertaking 1.
Clean air act section 111 socmi intermediate or final vocs 40 cfr 60. A large number of samples of herbs, spices and other dried vegetables imported to italy contained more than 0. Mannan ethylene oxide eo is a very versatile compound with considerable energy in its ring structure. Because it reacts readily with other chemicals, hpeo is one of the most versatile intermediates and is used to produce many derivative products. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Ethylene oxide, mustard gas and other organics, and to accelerate the ripening of fruits. Remove contaminated clothing and wash before reuse. Acute shortterm exposure to styrene oxide causes skin and eye irritation in humans. Exposure to ethylene oxide may cause headache, nausea, vomiting, diarrhea, breathing difficulty, drowsiness, weakness, exhaustion, eye and skin burns, frostbite, and reproductive effects. Ethylene oxide safety data sheet p4798 this sds conforms to u. This chapter describes the reproductive and developmental toxicity of eg. Uses advised against not for food, drug, pesticide or biocidal product use details of the supplier of.
Ethylene oxide also known as eo or eto processing is widely used for the sterilization of healthcare devices and instruments. Tumorigenicity according to iarc, there is strong evidence that the carcinogenicity of ethylene oxide, a directacting alkylating agent, operates by a genotoxic mechanism. This chemical is on the special health hazard substance list because it is flammable and reactive. Ethylene oxide eto for standards, pure or in known concentration i. Manufacture and uses of ethylene oxide and ethylene glycol. A crosslinked styrenedivinylbenzene anionexchange resin in the hco 3co 3 2form was used as a catalyst. Environmental releases ethylene emissions from industrial facilities are subject to.
It is intended to provide general information to persons who may handle or store ethylene oxide. Al069 air liquide australia limited level 9 380 st. Commercial sterilant mixtures are sold on a weightweight ratio. Understanding oshas exposure monitoring requirements osha 332501n 2007. Analytical methods the purpose of this chapter is to. Polybutylene oxide diblock copolymers at the interface between hydrophobic surfaces and water karin schillen, per m. Understanding oshas exposure monitoring requirements. When you collect an 8hour sample, osha expects you to collect the sample for the length of the whole work shift, no matter how long it is. Ethylene carbonate via coupling reaction with co 2 catalyzed by imidazolium zinc tetrahalides. Identification product name ethylene glycol cat no. For comparison, in alcohols the coh angle is about 110. The ethylene oxide hydration process in a catalytic fixed bed tube reactor was studied. It is used in the production of ethylene glycol and other oxide derivatives such as glycol ethers.
Ethylene oxide, iarc monographs on evaluation of carcinogenic risk in chemicals to humans, some industrial chemicals and dyestuffs, iarc,lyon, france vol 29, 1982 pp 7383. Ethylene oxide is a manmade chemical that is used primarily to make ethylene glycol a chemical used to make antifreeze and polyester. Clean air act section 112 for accidental release prevention 40 cfr 68. It is also an important intermediate in the the manufacture of certain detergents. Metal fittings containing magnesium, copper or silver should be avoided, since traces of acetylene in ethylene oxide may produce metal acetylides capable of detonating the vapor mca sd38, 1971. Ethylene oxide sds ref al069 air liquide australia limited level 9 380 st. These air samples will be referred to here as 15minute samples and 8hour samples. A similar method is reported by the occupational safety and health. Used to manufacture other chemicals, to sterilize medical devices, and as a fumigant. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. The types of functional fluids produced include heat transfer fluids, hydraulic fluids, and lubricants. No other significant interferences have been found 1. Analytical methods the purpose of this chapter is to describe the analytical methods that are available for detecting andor measuring and monitoring ethylene oxide in environmental media and in biological samples. Eo sterilization assures that a safe and sterile product will be delivered to the market each and every time.
The ethylene oxide product stewardship guidance manual was prepared by the american chemistry councils ethylene oxideethylene glycols panel panel. Studyhazard statement category 1 category 2 category 3 category 4 category 5. Chemical product and company identification product name. Ethylene oxide is usually stored andor transported as a liquid under pressure. Propylene oxide is also used to manufacture functional fluids by reaction of propylene oxide or mixtures of propylene oxide and ethylene oxide with glycols, glycerin, alcohols, and phenols. The deactivation and swelling of the catalyst during the. Equipment used for personal monitoring typically includes a.
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